Innovative Botulinum Toxin for Aesthetics and Therapeutics.
The highest level of toxin purity — 99.8%
About FORTOX
FORTOX is an advanced product based on Clostridium botulinum toxin type A, developed by YUMA MEDICAL LP for aesthetic and therapeutic correction.
How FORTOX Works
FORTOX acts as a neuromodulator, blocking the release of acetylcholine at neuromuscular junctions. This results in temporary muscle relaxation, reduction of hyperactivity, and correction of wrinkles or other conditions. A key feature is the low molecular weight of the complex-free toxin (150 kDa), with a complex size of only ±4 kDa (compared to ±45 kDa in Onabotulinumtoxin A). This ensures:
FORTOX Protocol
Minimal Diffusion
The toxin acts precisely at the injection site, reducing the risk of adverse effects on adjacent muscles.
Rapid Onset of Action
The effect appears within 2-3 days, peaking at day 7-14.
Long-lasting Result
Up to 4-6 months, depending on the area and dosage, thanks to the stable formula.
Low Molecular Weight Complex
The ±4 kDa size ensures precise localization of action, minimizing diffusion and allowing treatment of delicate areas (e.g., the periorbital region).
Biocompatibility
Free from animal proteins, with an endotoxin level 0.05 UE/g – hypoallergenic and biodegradable.
Balanced pH of the Toxin
The balanced pH ensures safe use of the product, minimizing irritation and discomfort while allowing procedures to be performed comfortably and effectively.
High Biological Activity
Fortox has high biological activity, promoting tissue regeneration, improving skin quality, and delivering reliable results.
Composition
1 vial / 100 units per vial. (Lyophilized white powder for reconstitution with sterile 0.9% solution)
Albumin
Sodium Chloride
Botulinum Toxin Type A
Molecular Mass
MOLECULAR MASS OF THE PROTEIN-TOXIN COMPLEX
Analysis confirms that levels of endotoxins, proteins, and nucleotides are significantly below permissible limits, demonstrating a high degree of biotechnological purification.
Molecular Profile
The molecular weight of the protein-toxin complex in FORTOX is 903.3 kDa (± 4 kDa).
Analysis confirms that levels of endotoxins, proteins, and nucleotides are significantly below permissible limits, demonstrating a high degree of biotechnological purification. Stable and Predictable Outcome
Clinical Study Results
According to the results of the clinical study, the FORTOX group of subjects noted higher effectiveness and overall satisfaction with the procedure for correcting glabellar wrinkles.
- Peak Name
- RT
- Area
- %Area
- Height
- Peak 1 W2489 ChA
- 15.250
- 4152357
- 99.81
- 53621
- Peak 2 W2489 ChA
- 19.200
- 8004
- 0.19
- 209
- Retention Time (min)
- Area
- %Area
- 9.250
- 1489506
- 98.99
- 10.662
- 15157
- 1.01
Indications for Use
Temporary correction of moderate to deep dynamic wrinkles
Glabellar lines and Venus rings (horizontal neck lines)
Botulinum
lifting
Blepharospasm
Correction of lip shape and facial asymmetry
Reduction of flushing associated with rosacea.
Significant reduction of sweating in hyperhidrosis of the axillae (underarms), palms, and feet.
Assessment of Study Participant Satisfaction (%)
Based on clinical study results, the participant group treated with Fortox reported higher efficacy and overall satisfaction with the glabellar muscle correction procedure.
U-100 Syringe:
Advantage:
each graduation = 1 unit of the product, making dosing intuitive even without a calculator.
Errors:
Minimal risk of dosage errors.
Capacity:
1 ml, 0.5 ml, or 0.3 ml.
Most frequently:
Most frequently used in botulinum therapy.
Syringe Specifications:
- Capacity (ml)
- Total Units (U)
- One Graduation Equals
- Advantages
- 0.3 ml
- 30
- 1 graduation = 1 unit
- Very clear scale, convenient for dose calculation
- 0.5 ml
- 50
- 1 graduation = 1 unit
- Balanced option: volume + precision.
- 1.0 ml
- 100
- 1 graduation = 1 unit
- Smaller graduations, harder to control small doses.
Key Characteristics and Properties of FORTOX
Dosage and Recommendations
Reconstitute the vial content with 0.9% sterile saline to obtain 1 ml or 2 ml of working solution.
- Standard Dose: One active dose of FORTOX consists of 3–4 units for facial wrinkle correction.
- Glabellar Area: For pronounced muscle activity in the glabellar area, the recommended dose is 6–8 units.
Note: The number of units per syringe graduation depends on the syringe type and the dilution volume.
Duration: The aesthetic effect lasts from 4 to 6 months.
Aesthetic indications
Hypokinesia of Mimic Muscles:
- Dynamic forehead wrinkles (m. frontalis)
- Vertical glabellar lines (m. corrugator supercilii, m. procerus)
- Periorbital wrinkles (m. orbicularis oculi) — “crow’s feet”
- Radial perioral wrinkles (m. orbicularis oris)
- Dynamic chin folds (m. mentalis)
- Dynamic chin folds (m. mentalis)
Facial Architecture Correction:
- Brow ptosis (brow lift via relaxation of m. corrugator)
- Enlargement of the lateral orbital fissure (lateral brow lift)
- Marionette line treatment (lifting the corners of the mouth)
- Narrowing of the lower third of the face (relaxation of m. masseter)
- Correction of facial muscle asymmetry
- Narrowing of the nasal wings and tip elevation
Medical indications
Neurological Disorders:
- Chronic migraine
- Bruxism and spasm of masticatory muscles — relaxation of m. masseter
- Muscle spasticity (stroke, cerebral palsy, spinal cord injury)
- Essential tremor
- Cervical dystonia
- Blepharospasm, hemispasm, and paraspasm
- Trapezius muscle spasm (TRAPTOX)
Dermatological Indications:
- Axillary hyperhidrosis — blockade of cholinergic transmission in sweat glands
- Palmar and plantar hyperhidrosis
- Craniofacial hyperhidrosis
Otolaryngological Indications:
- Vocal cord spasm (spastic dysphonia)
- Laryngeal dystonia
Get to Know FORTOX
Learn more about the benefits of FORTOX and its capabilities in aesthetic correction. Get professional insights to confidently integrate the product into your practice. Start working with a product designed for precise and predictable results.
